Find out if the TRIM-EBC clinical trial is right for you


What is TRIM-EBC?

The TRIM-EBC* clinical trial is studying whether weight loss from Zepbound® (tirzepatide) can lower the risk of breast cancer recurrence by reducing or clearing circulating tumor DNA (ctDNA).

How is ctDNA related to breast cancer?

Research has shown that people living with early-stage breast cancer who test positive for circulating tumor DNA (ctDNA) in their blood are at a higher risk for breast cancer recurrence.

People with obesity or who are overweight are also at an increased risk for breast cancer recurrence. 

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Who can participate in TRIM-EBC?

People who meet the following criteria may be eligible. These are the key requirements. There may be additional criteria the study team uses to determine eligibility.

  • You have ER-positive, HER2-negative, lymph node–positive, early breast cancer

  • You have obesity or are overweight with a BMI over 27 kg/m2

  • You test positive for ctDNA in the blood

  • You are not living with recurrent or metastatic cancer

How does the study work?

If you are interested in participating in the TRIM-EBC clinical trial, here is what you can expect: 

Step 1

Talk to the study team about your eligibility for clinical trial

Step 2

Provide a blood sample for ctDNA evaluation

Step 3

If ctDNA is not found, retest every 3 months for up to 3 years

Step 4

If ctDNA is found, you will have an imaging evaluation to check for metastasis

Step 5

Receive a weekly Zepbound injection while on the trial

Step 6

Periodic visits with the study team to monitor for weight loss, side effects, and ctDNA

Do you have questions? We have answers.

Participating in a clinical trial is a big decision. We want to make sure you have the answers you need to make the choice that’s right for you.

Is there a cost?

The cost associated with participation in this trial is for standard breast cancer care, including office visits and standard labs. You will not be charged for Zepbound or ctDNA blood tests. 

How long will I need to see the doctor and research team?

While you are taking Zepbound, we will need to see you once a month for the first 6 months of the study, and then every other month for up to 2 years.

Is Zepbound FDA approved?

Yes, Zepbound is approved by the FDA for the treatment of people with obesity or overweight with one or more comorbid conditions.

What if I change my mind?

You are free to change your mind and withdraw from the study at any time.

Have more questions?

For more information about TRIM-EBC or to see if you are eligible to enroll, contact our study team.